Effects of Cathepsin Proteolytic Network Dynamics on Extracellular Matrix Degradation in Biological Machines and Invasive Disease
IBB room 102 Atlanta, GA
- Aim 1: Distinguish proteolytic interactions between cathepsins K, L, S, and V among key substrates of collagen and elastin to develop a proteolytic network computational model.
- Aim 2: Determine the role of proteolytic activity in destabilizing locomoting biological machines.
- Aim 3: Determine the role of protease inhibitors in perturbing the cathepsin proteolytic network.
Advisor: Manu O. Platt